Research Article
Mucoadhesive Hydrogel Films of Econazole Nitrate: Formulation and Optimization Using Factorial Design
Table 4
Physical properties of MHFs.
| Batch code | Drug content* (%) | Microenvironment pH* | MHF thickness* (mm) | MHF weight* (mg) | Folding endurance* | Mucoadhesive strength** (gm/cm2) | In vitro residence time** (minute) |
| EF1 | 99.21 ± 0.94 | 7.32 ± 0.12 | 0.32 ± 0.08 | 194 ± 1.41 | >300 | 106.22 ± 3.98 | 334 ± 34 | EF2 | 100.01 ± 0.45 | 7.30 ± 0.22 | 0.33 ± 0.05 | 196 ± 2.12 | >300 | 102.67 ± 5.67 | 321 ± 19 | EF3 | 99.34 ± 0.65 | 7.21 ± 0.14 | 0.32 ± 0.07 | 195 ± 1.87 | >300 | 93.78 ± 2.12 | 298 ± 21 | EF4 | 99.78 ± 0.87 | 7.29 ± 0.19 | 0.48 ± 0.08 | 211 ± 0.80 | >300 | 122.67 ± 5.34 | 469 ± 38 | EF5 | 98.98 ± 0.91 | 7.36 ± 0.20 | 0.47 ± 0.11 | 213 ± 0.68 | >300 | 118.67 ± 8.90 | 421 ± 41 | EF6 | 100.45 ± 0.45 | 7.39 ± 0.12 | 0.47 ± 0.12 | 213 ± 1.09 | >300 | 115.11 ± 4.12 | 409 ± 25 | EF7 | 99.16 ± 0.73 | 7.40 ± 0.25 | 0.61 ± 0.05 | 226 ± 1.06 | >300 | 153.33 ± 7.09 | 734 ± 47 | EF8 | 99.56 ± 0.56 | 7.41 ± 0.18 | 0.60 ± 0.11 | 228 ± 2.05 | >300 | 137.33 ± 4.23 | 718 ± 24 | EF9 | 98.99 ± 0.90 | 7.40 ± 0.26 | 0.61 ± 0.03 | 227 ± 1.15 | >300 | 128.89 ± 6.39 | 689 ± 30 |
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