Mucoadhesive Hydrogel Films of Econazole Nitrate: Formulation and Optimization Using Factorial Design

Table 4

Physical properties of MHFs.

Batch code	Drug content* (%)	Microenvironment pH*	MHF thickness* (mm)	MHF weight* (mg)	Folding endurance*	Mucoadhesive strength**  (gm/cm^2)	In vitro residence time** (minute)
EF1	99.21 ± 0.94	7.32 ± 0.12	0.32 ± 0.08	194 ± 1.41	>300	106.22 ± 3.98	334 ± 34
EF2	100.01 ± 0.45	7.30 ± 0.22	0.33 ± 0.05	196 ± 2.12	>300	102.67 ± 5.67	321 ± 19
EF3	99.34 ± 0.65	7.21 ± 0.14	0.32 ± 0.07	195 ± 1.87	>300	93.78 ± 2.12	298 ± 21
EF4	99.78 ± 0.87	7.29 ± 0.19	0.48 ± 0.08	211 ± 0.80	>300	122.67 ± 5.34	469 ± 38
EF5	98.98 ± 0.91	7.36 ± 0.20	0.47 ± 0.11	213 ± 0.68	>300	118.67 ± 8.90	421 ± 41
EF6	100.45 ± 0.45	7.39 ± 0.12	0.47 ± 0.12	213 ± 1.09	>300	115.11 ± 4.12	409 ± 25
EF7	99.16 ± 0.73	7.40 ± 0.25	0.61 ± 0.05	226 ± 1.06	>300	153.33 ± 7.09	734 ± 47
EF8	99.56 ± 0.56	7.41 ± 0.18	0.60 ± 0.11	228 ± 2.05	>300	137.33 ± 4.23	718 ± 24
EF9	98.99 ± 0.90	7.40 ± 0.26	0.61 ± 0.03	227 ± 1.15	>300	128.89 ± 6.39	689 ± 30

^∗𝑛=5.
^∗∗𝑛=3.