Mucoadhesive Hydrogel Films of Econazole Nitrate: Formulation and Optimization Using Factorial Design

Table 7

Kinetic constants, time required to 50% ECN release (𝑇_50%), and ECN release at 8th hour (Rel_8hr).

Kinetic profile of MHFs	Higuchi eq.	Korsmeyer-Peppas eq.			First order eq.		Zero order eq.		𝑇50% (hr)	Rel8hr; (CPR)
	𝑅^2	𝑛	𝑘	𝑅^2	𝑘	𝑅^2	𝑘	𝑅^2
Desirability	0.977	1.00	6.25	1.000	−0.04	0.949	6.25	1.000	8.00	50.00
EF1	0.925	0.58	21.17	0.929	−0.06	0.876	8.20	0.623	3.44	72.95
EF2	0.976	0.63	17.62	0.973	−0.06	0.960	7.75	0.782	4.62	68.52
EF3	0.995	0.67	14.60	0.995	−0.05	0.993	7.09	0.884	5.75	60.95
EF4	0.993	0.66	14.17	0.997	−0.05	0.993	6.82	0.930	6.86	55.65
EF5	0.963	0.83	8.93	0.990	−0.04	0.954	6.34	0.995	7.76	51.76
EF6	0.980	0.65	12.27	0.994	−0.04	0.984	5.90	0.940	8.57	47.48
EF7	0.984	0.66	10.70	0.996	−0.03	0.983	5.13	0.933	10.36	40.74
EF8	0.987	0.67	9.45	0.996	−0.03	0.988	4.66	0.943	11.45	37.72
EF9	0.989	0.67	7.64	0.998	−0.02	0.979	3.79	0.936	14.21	30.54