Mucoadhesive Hydrogel Films of Econazole Nitrate: Formulation and Optimization Using Factorial Design

Table 8

Diameter of zone of inhibition of optimized MHF.

Time (hr)	0	1	2	3	4	6	8	10	12
Diameter of zone of inhibition* (mm)	0	2.11 ± 0.56	3.24 ± 0.56	4.21 ± 0.24	5.44 ± 0.09	8.24 ± 0.79	11.39 ± 0.70	14.16 ± 0.82	16.57 ± 0.59
Corresponding percent drug release*	0	9.63 ± 0.89	14.79 ± 0.81	19.22 ± 0.33	24.84 ± 0.19	37.62 ± 1.08	52.00 ± 0.99	64.65 ± 1.14	75.65 ± 0.67

^∗𝑛=3.