Tailor-Made Pentablock Copolymer Based Formulation for Sustained Ocular Delivery of Protein Therapeutics
Figure 19
Cell migration assay performed on RF/6A cells to evaluate the biological activity of bevacizumab (a) fluorescence intensity indicating number of migrated cells, (b) images of migrated cells stained by methylene blue including (1) negative control (untreated cells), (2) standard (cells exposed to 100 ng/mL of VEGF and 0.25 mg/mL of bevacizumab), (3) sample (cells exposed to 100 ng/mL of VEGF and 0.25 mg/mL of released bevacizumab), and (4) positive control (cell exposed to 100 ng/mL VEGF). Results are described in mean ± SD, .
