Preparation and Characterization of Liquisolid Compacts for Improved Dissolution of Telmisartan

Table 2

Solubility of telmisartan at different solvents and media (mean ± SD; ).

Media	Solubility (mg/mL)	Nonvolatile solvents	Solubility (mg/mL)
Distilled water (pH 6.8)	0.022 ± 0.02	Tween 20	4.2 ± 0.61
0.1 N HCl (pH 1.2)	0.549 ± 0.04	Tween 80	5.5 ± 0.45
Acetate buffer (pH 4.5)	0.033 ± 0.01	PEG 200	9.2 ± 0.86
Acetate buffer with 0.5% SLS (pH 4.5)	0.233 ± 0.09	PEG 600	8.8 ± 0.22
Saline phosphate buffer (PBS) (pH 7.4)	0.013 ± 0.01	Propylene glycol	3.2 ± 0.9
PBS with 0.5% SLS (pH 7.4)	0.108 ± 0.04	Transcutol P	6.1 ± 0.42