Research Article
Design and Evaluation of Polyox and Pluronic Controlled Gastroretentive Delivery of Troxipide
Table 2
Formulation of gastroretentive floating tablet.
| | Batch code | Coded level | Pluronic F127 (mg) | Polyox WSR 205 (mg) | Sodium bicarbonate (mg) | Citric acid (mg) | Magnesium stearate (mg) | Talc (mg) | Di calcium phosphate (mg) | | Variable 1 (Pluronic F127) | Variable 2 (Polyox WSR 205) |
| | F1 | − | − | 25.2 | 135 | 58 | 10 | 1 | 1 | 36 | | F2 | − | | 25.2 | 145 | 58 | 10 | 1 | 1 | 26 | | F3 | − | + | 25.2 | 153 | 58 | 10 | 1 | 1 | 18 | | F4 | | − | 35 | 135 | 58 | 10 | 1 | 1 | 26 | | F5 | | | 35 | 145 | 58 | 10 | 1 | 1 | 16 | | F6 | | + | 35 | 153 | 58 | 10 | 1 | 1 | 8 | | F7 | + | − | 43.2 | 135 | 58 | 10 | 1 | 1 | 18 | | F8 | + | | 43.2 | 145 | 58 | 10 | 1 | 1 | 8 | | F9 | + | + | 43.2 | 153 | 58 | 10 | 1 | 1 | 0 |
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Weight is expressed as mg per tablet. Total weight of tablet was 370 mg.
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