Research Article
Formulation and Evaluation of Optimized Oxybenzone Microsponge Gel for Topical Delivery
Table 1
Factorial design and characterization of experimental formulations.
| Formulations (EC, DCM) (mg, mL) | % EE ± SD | % DC ± SD | % production yield | Particle size (0.9) m ± SD | % DR ± SD |
| M1 (100, 3) | 92.3 ± 0.12 | 67.12 ± 0.42 | 50.14 ± 0.28 | 496 ± 0.12 | 20.08 ± 0.02 | M2 (100, 5) | 93.7 ± 0.22 | 70.00 ± 0.56 | 59.76 ± 0.10 | 619 ± 0.02 | 21.08 ± 0.82 | M3 (100, 7) | 98.6 ± 0.14 | 73.54 ± 0.82 | 73.54 ± 0.16 | 146 ± 0.32 | 22.28 ± 0.72 | M4 (200, 3) | 90.1 ± 0.21 | 44.26 ± 0.42 | 44.10 ± 0.14 | 347 ± 0.42 | 12.19 ± 0.42 | M5 (200, 5) | 96.3 ± 0.56 | 67.54 ± 0.32 | 67.76 ± 0.72 | 224 ± 0.52 | 12.88 ± 0.32 | M6 (200, 7) | 98.5 ± 0.72 | 54.28 ± 0.22 | 55.22 ± 0.32 | 105 ± 0.62 | 13.74 ± 0.42 | M7 (300, 3) | 95.3 ± 0.92 | 65.33 ± 0.29 | 65.11 ± 0.42 | 272 ± 0.02 | 12.23 ± 0.02 | M8 (300, 5) | 96.7 ± 0.62 | 42.02 ± 0.12 | 42.78 ± 0.62 | 119 ± 0.28 | 12.94 ± 0.11 | M9 (300, 7) | 96.9 ± 0.52 | 77.87 ± 0.92 | 77.56 ± 0.20 | 072 ± 0.77 | 13.76 ± 0.10 |
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