Investigation of Fatty Acid Ketohydrazone Modified Liposome’s Properties as a Drug Carrier

Figure 5

Alteration of membrane properties with dropping pH. Membrane properties were evaluated by membrane fluidity (, anisotropy of DPH fluorescence) and hydrophilic/hydrophobic environment ( values calculated by Laurdan fluorescence intensity) of liposomal membrane. 2~4 and 5~7 show the physicochemical properties of P-KH liposome and S-KH liposome in PBS, and 2′~4′ and 5′~7′ show that of P-KH liposome and S-KH liposome at pH 5.0.