Characterization and Compatibility Studies of Different Rate Retardant Polymer Loaded Microspheres by Solvent Evaporation Technique: In Vitro-In Vivo Study of Vildagliptin as a Model Drug

Table 2

Release rate constants and correlation coefficient () values of different formulations of Vildagliptin microspheres using different polymers by emulsion solvent evaporation technique, respectively.

Formulation code	Rate constants and -squared values
	Zero order		First order		Higuchi		Korsmeyer-Peppas
	VF1	9.83	0.983	−0.218	0.919	29.81	0.96	0.62	0.991
VF2	9.73	0.979	−0.211	0.951	29.7	0.974	0.61	0.995
VF3	9.8	0.981	−0.209	0.969	30.06	0.98	0.64	0.994
VF4	9.97	0.979	−0.221	0.929	30.57	0.98	0.63	0.994
VF5	10.35	0.988	−0.211	0.957	31.33	0.963	0.67	0.991
VF6	10.67	0.984	−0.204	0.964	32.54	0.973	0.66	0.993
VF10	10.4	0.989	−0.225	0.925	31.51	0.966	0.75	0.991
VF11	9.39	0.951	−0.221	0.944	29.16	0.976	0.67	0.995
VF12	8.48	0.988	−0.218	0.965	25.54	0.959	0.7	0.994
VF13	11.13	0.993	−0.222	0.945	33.51	0.958	0.78	0.995
VF14	10.6	0.981	−0.225	0.954	32.37	0.973	0.77	0.995
VF15	9.86	0.987	−0.231	0.924	29.05	0.912	0.76	0.992