Calcium Alginate-Neusilin US2 Nanocomposite Microbeads for Oral Sustained Drug Delivery of Poor Water Soluble Drug Aceclofenac Sodium

Table 3

Composition and physical characteristics of drug loaded nanocomposite microbeads.

Formulation code	S. A	Neusilin US2	Calcium chloride	Actual drug content	DEE
	(%w/w)	(%w/w)	(%w/v)	(mg/50 mg)	(%w/w)
AF-1	0.5	—	4	29.56 ± 0.33	59.12 ± 0.35
AF-2	1.0	—	4	37.65 ± 0.15	75.30 ± 0.56
AF-3	1.5	—	4	44.85 ± 0.28	89.70 ± 0.36
AF-4	2.0	—	4	46.65 ± 0.62	93.30 ± 0.55
AF-5	1.5	0.4	4	45.95 ± 0.12	91.90 ± 0.25
AF-6	1.5	0.6	4	47.45 ± 0.55	94.90 ± 0.55
AF-7	1.5	1.0	4	49.25 ± 0.32	98.50 ± 0.09
AF-8	1.5	1.5	4	49.75 ± 0.25	99.50 ± 0.05
AF-9	1.5	1.0	0.5	47.30 ± 0.87	94.60 ± 0.69
AF-10	1.5	1.0	2	46.80 ± 0.74	93.60 ± 1.14
AF-11	1.5	1.0	4	45.40 ± 0.14	91.82 ± 1.04
AF-12	1.5	1.0	6	44.60 ± 0.42	89.20 ± 1.07

All the formulations contain 200 mg of aceclofenac sodium. Data are expressed ± S.D. .