Calcium Alginate-Neusilin US2 Nanocomposite Microbeads for Oral Sustained Drug Delivery of Poor Water Soluble Drug Aceclofenac Sodium

Table 4

Effect of various kinetic models on drug release.

Formulation code	Effect of various kinetic models on drug release
	Zero-Order	First-Order	Higuchi matrix	Korsmeyer-Peppas	Korsmeyer-Peppas
					-values	-values
F1	0.9117	0.9114	0.9124	0.9762	0.7248	2.7889
F2	0.9209	0.9174	0.9113	0.9801	0.7456	2.6783
F3	0.9392	0.9221	0.9108	0.9840	0.7515	2.4240
F4	0.9474	0.9329	0.9103	0.9950	0.7711	2.0693
F5	0.9521	0.9830	0.9097	0.9257	0.7764	1.9066
F6	0.9399	0.9803	0.9082	0.9291	0.6535	2.0130
F7	0.9372	0.9811	0.9088	0.9262	0.5449	2.1643
F8	0.9278	0.9801	0.9076	0.9217	0.5523	2.2625
F9	0.9129	0.9475	0.9702	0.9148	0.6482	2.4075
F10	0.9007	0.9568	0.9720	0.9115	0.7361	2.6019
F11	0.9826	0.9624	0.9842	0.9162	0.8704	2.8220
F12	0.9846	0.9700	0.9868	0.9153	0.8788	2.6173

All the results show S.D. ; : diffusion exponent (slope) related to mechanism of drug release, according to equation , and : regression coefficient.