Formulation and In Vitro Evaluation of Bilayer Tablets of Nebivolol Hydrochloride and Nateglinide for the Treatment of Diabetes and Hypertension

Table 18

Kinetic data analysis of Nebivolol (immediate release) layer in bilayer tablet.

Zero order		First order		Higuchi		Korsemeyer
Time (min)	Cum. %release	Time (min)	Log cum. %remaining	Sqrt. of time	Cum. %drug release	Log of time	Log cum. %release
0	0	0	0	0	0	0	0
5	25.45	5	1.872447648	2.236067977	25.45	0.698970004	1.405687787
10	48.37	10	1.712902125	3.16227766	48.37	1	1.684576087
15	69.28	15	1.487421211	3.872983346	69.28	1.176091259	1.840607879
20	84.61	20	1.18723862	4.472135955	84.61	1.301029996	1.927421695
25	91.02	25	0.953276337	5	91.02	1.397940009	1.959136831
30	97.43	30	0.409933123	5.477225575	97.43	1.477121255	1.988692703