Research Article
Formulation and In Vitro Evaluation of Bilayer Tablets of Nebivolol Hydrochloride and Nateglinide for the Treatment of Diabetes and Hypertension
Table 18
Kinetic data analysis of Nebivolol (immediate release) layer in bilayer tablet.
| Zero order | First order | Higuchi | Korsemeyer | Time (min) | Cum. %release | Time (min) | Log cum. %remaining | Sqrt. of time | Cum. %drug release | Log of time | Log cum. %release |
| 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 25.45 | 5 | 1.872447648 | 2.236067977 | 25.45 | 0.698970004 | 1.405687787 | 10 | 48.37 | 10 | 1.712902125 | 3.16227766 | 48.37 | 1 | 1.684576087 | 15 | 69.28 | 15 | 1.487421211 | 3.872983346 | 69.28 | 1.176091259 | 1.840607879 | 20 | 84.61 | 20 | 1.18723862 | 4.472135955 | 84.61 | 1.301029996 | 1.927421695 | 25 | 91.02 | 25 | 0.953276337 | 5 | 91.02 | 1.397940009 | 1.959136831 | 30 | 97.43 | 30 | 0.409933123 | 5.477225575 | 97.43 | 1.477121255 | 1.988692703 |
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