Formulation and In Vitro Evaluation of Bilayer Tablets of Nebivolol Hydrochloride and Nateglinide for the Treatment of Diabetes and Hypertension

Table 2

Composition of Nebivolol immediate release tablets (150 mg).

Batch code	Ingredients in mg/tablet
	Drug	MCC	CP	CCS	SSG	Mg. stearate	SLS	Fe2O3
NBL-1	10	131	7.5	—	—	1.5	—	Qs
NBL-2	10	123.5	15	—	—	1.5	—	Qs
NBL-3	10	131	—	7.5	—	1.5	—	Qs
NBL-4	10	123.5	—	15	—	1.5	—	Qs
NBL-5	10	131	—	—	7.5	1.5	—	Qs
NBL-6	10	123.5	—	—	15	1.5	—	Qs
NBL-7	10	119.5	—	—	18.75	1.5	—	Qs
NBL-8	10	131	—	—	7.5	1.5	0.3	Qs
NBL-9	10	123.5	—	—	15	1.5	0.3	Qs

MCC: microcrystalline cellulose, CP: Crospovidone, CCS: Croscarmellose sodium, SSG: sodium starch glycolate, SLS: sodium lauryl sulfate.