Formulation and In Vitro Evaluation of Bilayer Tablets of Nebivolol Hydrochloride and Nateglinide for the Treatment of Diabetes and Hypertension

Table 20

Stability studies.

S. number	Parameters	Conditions
		Initial	40^°C/75%RH
		0 days	1 month	2 months	3 months
		Nebivolol and Nateglinide bilayer tablet
1	Average weight (mg)	450 ± 5.0	450 ± 5.0	450 ± 5.0	450 ± 5.0
2	Hardness (kg/cm^2)	6.5 ± 0.5	6.5 ± 0.5	6.3 ± 0.5	6.0 ± 0.5
3	Thickness (mm)	5.36 ± 0.04	5.34 ± 0.05	5.34 ± 0.08	5.34 ± 0.08
4	Dissolution (cum.% drug release)
	Nebivolol (30 min)	97 ± 3.43	97 ± 3.15	96 ± 3.24	96 ± 3.65
	Nateglinide (12 hrs)	97 ± 3.22	97 ± 3.83	96 ± 3.67	96 ± 3.48