Formulation and In Vitro Evaluation of Bilayer Tablets of Nebivolol Hydrochloride and Nateglinide for the Treatment of Diabetes and Hypertension

Table 7

Solubility study data of Nebivolol and Nateglinide in various solvents and buffers.

Name of solvent/buffer	Nebivolol (mg/mL)	Nateglinide (mg/mL)
Water	0.0017	0.001
HCl buffer pH 1.2	1.2234	0.105
Phosphate buffer pH 6.8	0.0012	0.021
PEG	0.9102	—
DMSO	0.4567	0.574
Methanol	0.0814	0.342