Formulation and <i>In Vitro</i> Evaluation of Bilayer Tablets of Nebivolol Hydrochloride and Nateglinide for the Treatment of Diabetes and Hypertension

<table class="table-group" id="tab9"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td align="left">Functional groups</td><td align="center">Reported value (cm<sup>−1</sup>)</td><td align="center">Observed value (cm<sup>−1</sup>)<br/>Pure drug</td><td align="center">Observed value (cm<sup>−1</sup>)<br/>Optimized formula</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td align="left">COOH</td><td align="center">3300–2500</td><td align="center">3123.24</td><td align="center">3126.84</td></tr><tr><td align="left">Carbonyls</td><td align="center">1760–1665</td><td align="center">1690.97</td><td align="center">1691.56</td></tr><tr><td align="left">Nitro compounds</td><td align="center">1550–1475</td><td align="center">1487.80</td><td align="center">1488.00</td></tr><tr><td align="left">Aliphatic amines</td><td align="center">1550–1475</td><td align="center">1150.20</td><td align="center">1150.63</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Characteristic peak of Nateglinide pure drug and optimized formula.

Journal of Drug Delivery

tab9

Table 9

Table 9: Formulation and <i>In Vitro</i> Evaluation of Bilayer Tablets of Nebivolol Hydrochloride and Nateglinide for the Treatment of Diabetes and Hypertension 

Table 9 | Formulation and In Vitro Evaluation of Bilayer Tablets of Nebivolol Hydrochloride and Nateglinide for the Treatment of Diabetes and Hypertension 