Sustained Release of Protein Therapeutics from Subcutaneous Thermosensitive Biocompatible and Biodegradable Pentablock Copolymers (PTSgels)

Figure 4

In vitro release of IgG from pentablock copolymers (PTSgel). Mean SD of cumulative release (a) and daily release of IgG from PTSgel on a log scale (b) and on a linear scale (c). Using 20 mg/mL IgG in 22.5% PTSgel maintained at 37°C, half of overlaid PBS buffer was removed and replaced at days 1, 2, 3, 4, 5, 7, 10, and 14 and then weekly thereafter.

(a)

(b)

(c)