Stabilized Polymer Micelles for the Development of IT-147, an Epothilone D Drug-Loaded Formulation

Table 2

Plasma pharmacokinetic screening of pilot epothilone D formulations compared to free drug. A cannulated rat model was used to determine the AUC, , and Clast of epothilone D in plasma for the first hour after administration.

Test article	Animals per group	Dose (mg/kg)	(hµg/mL)	(µg/mL)	Clast (µg/mL)
NHOH micelle	3	10	18.9	42.7 ± 4.9	7.7 ± 0.2
Cys micelle	3	10	10.6	34.0 ± 11.0	4.8 ± 1.1
Free drug	3	10	5.2	19.7 ± 4.1	1.6 ± 0.8