Design, Characterization, and Optimization of Controlled Drug Delivery System Containing Antibiotic Drug/s

Table 12

Results of stability study of optimized batch (F22).

Evaluation parameters	Initially	After 30 days
Weight variation ()	430 ± 1.2	429 ± 3.3
Diameter (mm)	10.0 ± 0.05	10.0 ± 0.05
Thickness (mm)	5.0 ± 0.2	5.0 ± 0.1
Hardness (kg/cm^2)	6.8 ± 0.2	6.7 ± 0.5
Friability (%)	0.49	0.52
% drug content	97.2 ± 3.8	97.0 ± 1.3
1 (% drug release at 1 hr)	28.56%	30.07%
2 (% drug release at 6 hr)	61.81%	60.37%
3 (% drug release at 12 hr)	95.72%	93.88%