Deformable Nanovesicles Synthesized through an Adaptable Microfluidic Platform for Enhanced Localized Transdermal Drug Delivery

Figure 4

AF647-Zol calvarial bone distribution. The AF647-Zol signal is the greatest with DNV delivery (a) of the 3 methods used. The signal is reduced with either conventional NV delivery (b) or delivery of free aqueous AF647-Zol (c); in fact aqueous delivery appears to be slightly more effective than NV delivery. The skull anatomy is shown with the region of interest (ROI) circled (d). AF647 signal levels in the ROI were quantified (e), revealing DNV delivery is significantly () greater than either NV or aqueous delivery.