About this Journal Submit a Manuscript Table of Contents
Experimental Diabetes Research
Volume 2007 (2007), Article ID 95103, 14 pages
http://dx.doi.org/10.1155/2007/95103
Review Article

Contributions of Inflammatory Processes to the Development of the Early Stages of Diabetic Retinopathy

1Department of Medicine, Case Western Reserve University, Cleveland 44106-5029, OH, USA
2Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland 44106-5068, OH, USA
3Cleveland VA Medical Center, 10701 East Boulevard, Cleveland 44106, OH, USA

Received 14 January 2007; Accepted 27 May 2007

Academic Editor: Subrata Chakrabarti

Copyright © 2007 Timothy S. Kern. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Diabetes causes metabolic and physiologic abnormalities in the retina, and these changes suggest a role for inflammation in the development of diabetic retinopathy. These changes include upregulation of iNOS, COX-2, ICAM-1, caspase 1, VEGF, and NF-κB, increased production of nitric oxide, prostaglandin E2, IL-1β, and cytokines, as well as increased permeability and leukostasis. Using selective pharmacologic inhibitors or genetically modified animals, an increasing number of therapeutic approaches have been identified that significantly inhibit development of at least the early stages of diabetic retinopathy, especially occlusion and degeneration of retinal capillaries. A common feature of a number of these therapies is that they inhibit production of inflammatory mediators. The concept that localized inflammatory processes play a role in the development of diabetic retinopathy is relatively new, but evidence that supports the hypothesis is accumulating rapidly. This new hypothesis offers new insight into the pathogenesis of diabetic retinopathy, and offers novel targets to inhibit the ocular disease.