Recent Insights in Islet Amyloid Polypeptide-Induced Membrane Disruption and Its Role in -Cell Death in Type 2 Diabetes Mellitus
Figure 1
Comparison of the amino acid sequences of human
IAPP (hIAPP) and mouse IAPP (mIAPP). Mouse IAPP differs from the human peptide
by six residues (in red). The N-terminal region is thought to be responsible for membrane interaction (residues in blue). The amino acid region
suggested to be important for fibril formation is represented in the underlined.