Recent Insights in Islet Amyloid Polypeptide-Induced Membrane Disruption and Its Role in -Cell Death in Type 2 Diabetes Mellitus
Figure 2
Typical shape of the kinetics of hIAPP fibril formation, characterized by a lag
phase and a sigmoidal transition. The approximate aggregation state of IAPP is
indicated at the various time points. Fibril formation was induced by adding,
at time 0, a monomeric stock solution of hIAPP in DMSO to buffer containing Thioflavin T.