Transthyretin and Amyloid in the Islets of Langerhans in Type-2 Diabetes
Figure 2
Normal human islets immunolabeled with antisera against: (a)
transthyretin and (b) glucagon. In (c) is shown a normal human
islet, subjected to in situ hybridization with a TTR probe,
visualized with immunohistochemistry. Note that positive cells have
a distribution indicative of glucagon cells. Bar 20. (d)
shows a part of a glucagon cell with typical granules. The section
was double immunolabeled for glucagon (10 nm gold particles) and TTR
(5 nm gold particles). Immunolabeling for both these substances is
seen on the granules, bar 500 nm.
