Amyloid Deposition in Transplanted Human Pancreatic Islets: A Conceivable Cause of Their Long-Term Failure

Figure 5

Polarized light microscopic image of a Congo red stained microencapsulated human islet residing in the renal subcapsular space of an athymic nude mouse for four weeks. The black arrow points out amyloid in and outside a normal islet cell, whereas the white arrow indicates amyloid in the central necrotic part of the islet. Surrounding the islet is the alginate capsule (AC), and in the lower part of the image the renal capsule (RC).