Human Islet Amyloid Polypeptide Transgenic Mice: In Vivo and Ex Vivo Models for the Role of hIAPP in Type 2 Diabetes Mellitus
Figure 2
In situ mRNA hybridization (using radiolabeled oligoprobes) for hIAPP (a), (b), and GLUT-2 (c), (d) in islets of
nontransgenic (a), (c), and hIAPP transgenic (b), (d) female mice after 14 months
on high-fat diet. Note that hIAPP mRNA expression is absent in the nontransgenic
islet, and that GLUT-2 mRNA expression is reduced in
the transgenic islet. Scale bar = 30 μm.
