Identification of Compounds That Inhibit IGF-I Signaling in Hyperglycemia

Table 1

Ranking of compounds that accelerate IAP cleavage.

Number	Compound	ED50 (𝜇M)	Active range (𝜇M)	Mean % increase in R593 binding (5 𝜇M)
1	l-leucyl alanine	0.5	0.2–10	96±0.8
2	n-formyl methionyl leucyl phenylalanine	0.75	0.2–10	100±5
3	Mephentermine sulfate	1	0.2–10	90±5
4	Lysyl tyrosyl lysine acetate	2	0.2–10	75±20
5	Dopamine hydrochloride	2	1–10	84±8
6	N formyl methionyl phenylalanine	2	1–10	75±5
7	Dyclonine hydrochloride	2.5	1–10	92±8
8	Amoxicillin	3	1–10	85±2
9	Hydralazine hydrochloride	3	1–10	76±7.5
10	Cephaloride	4	2–10	65±5
11	Dinitolmide	5	2–10	35±12
12	Acetyl cysteine	6	2–10	30±5
13	Pyridostigmine bromide	6.5	1–10	30±1
14	Chloropromazine	7	2–10	25±2