The Roles of Streptozotocin Neurotoxicity and Neutral Endopeptidase in Murine Experimental Diabetic Neuropathy
Table 1
Effect of 3-O-methyl-glucose on Markers for Diabetic Neuropathy in Streptozotocin-treated C57Bl/6 and Swiss Webster Mice.
C57Bl/6
Control (10)
Diabetic (15)
3-O-methyl-glucose (15)
Start weight (g)
25. ± 0.7
26.9 ± 0.4
25.4 ± 0.5
End weight (g)
30.6 ± 1.0
25.7 ± 0.8
29.6 ± 0.5
Blood glucose (mg/dL)
175 ± 8
582 ± 6
214 ± 27
Insulin (pM)
10.6 ± 3.4
0.7 ± 0.3
12.8 ± 3.0
MNCV (m/sec)
33.6 ± 2.2
21.6 ± 1.2
35.7 ± 1.6
SNCV
23.2 ± 0.8
18.6 ±0.4
22.8 ± 0.5
Thermal response latency (sec)
6.70 ± 0.40
12.08 ± 0.92
7.21 ± 0.27
Swiss Webster
Control (9)
Diabetic (9)
3-O-methyl-glucose (9)
Start weight (g)
27.8 ± 0.6
29.0 ± 0.7
27.4 ± 0.4
End weight (g)
32.1 ± 1.3
24.6 ± 0.4
32.3 ± 1.0
Blood glucose (mg/dL)
182 ± 24
573 ± 27
226 ± 14
MNCV (m/sec)
47.8 ± 1.2
38.8 ± 1.4
46.4 ± 1.7
Thermal response latency week 4 (sec)
5.6 ± 0.4
8.8 ± 0.7
5.0 ± 0.6
Thermal response latency week 8 (sec)
4.9 ± 0.4
7.7 ± 0.9
5.8 ± 0.4
Data are presented as the mean ± SEM. compared to control for the respective group, compared to diabetic. Parentheses indicate the number of experimental animals.
