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- Table of Contents
Experimental Diabetes Research
Volume 2009 (2009), Article ID 835650, 10 pages
Sequence Variation and Expression of the Gimap Gene Family in the BB Rat
1Diabetes and Endocrinology Research Center, University of Washington, 815 Mercer Street, Building A, S130, Seattle, WA 98109, USA
2Department of Biological and Chemical Sciences, Salish Kootenai College, 58138 Hwy 93, Pablo, P.O. Box 70, MT 59855, USA
3Department of Clinical Sciences, Clinical Research Center, Lund University, Entrance 72, Building 91:10, 20502 Malmö, Sweden
4Department of Medicine, University of Washington, 1959 N.E. Pacific Street, Seattle, P.O. Box 357710, WA 98195, USA
5Department of Comparative Medicine, University of Washington, 1959 N.E. Pacific Street, Seattle, P.O. Box 357190, WA 98195, USA
6Department of Internal Medicine, University of Iowa, 375 Newton Road, 3111B MERF, Iowa City, IA 52242, USA
Received 9 December 2008; Accepted 8 February 2009
Academic Editor: Anjan Kowluru
Copyright © 2009 Elizabeth A. Rutledge et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- H. Markholst, S. Eastman, D. Wilson, B. E. Andreasen, and Å. Lernmark, “Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes,” The Journal of Experimental Medicine, vol. 174, no. 1, pp. 297–300, 1991.
- A. J. MacMurray, D. H. Moralejo, A. E. Kwitek, et al., “Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene,” Genome Research, vol. 12, no. 7, pp. 1029–1039, 2002.
- J. Krücken, R. M. U. Schroetel, I. U. Müller, et al., “Comparative analysis of the human gimap gene cluster encoding a novel GTPase family,” Gene, vol. 341, no. 1-2, pp. 291–304, 2004.
- J. M. Fuller, A. E. Kwitek, T. J. Hawkins, et al., “Introgression of F344 rat genomic DNA on BB rat chromosome 4 generates diabetes-resistant lymphopenic BB rats,” Diabetes, vol. 55, no. 12, pp. 3351–3357, 2006.
- D. H. Moralejo, H. A. Park, S. J. Speros, et al., “Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat,” Journal of Autoimmunity, vol. 21, no. 4, pp. 315–324, 2003.
- L. Hornum, J. Rmer, and H. Markholst, “The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1,” Diabetes, vol. 51, no. 6, pp. 1972–1979, 2002.
- M. Michalkiewicz, T. Michalkiewicz, R. A. Ettinger, et al., “Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat,” Physiological Genomics, vol. 19, no. 2, pp. 228–232, 2004.
- M. Pandarpurkar, L. Wilson-Fritch, S. Corvera, et al., “Ian4 is required for mitochondrial integrity and T cell survival,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 18, pp. 10382–10387, 2003.
- S. Ilangumaran, M. Forand-Boulerice, S. M. Bousquet, et al., “Loss of GIMAP5 (GTPase of immunity-associated nucleotide binding protein 5) impairs calcium signaling in rat T lymphocytes,” Molecular Immunology, vol. 46, no. 6, pp. 1256–1259, 2009.
- U. Dalberg, H. Markholst, and L. Hornum, “Both Gimap5 and the diabetogenic BBDP allele of Gimap5 induce apoptosis in T cells,” International Immunology, vol. 19, no. 4, pp. 447–453, 2007.
- M. Keita, C. Leblanc, D. Andrews, and S. Ramanathan, “GIMAP5 regulates mitochondrial integrity from a distinct subcellular compartment,” Biochemical and Biophysical Research Communications, vol. 361, no. 2, pp. 481–486, 2007.
- R. Kupfer, J. Lang, C. Williams-Skipp, M. Nelson, D. Bellgrau, and R. I. Scheinman, “Loss of a gimap/ian gene leads to activation of NF-B through a MAPK-dependent pathway,” Molecular Immunology, vol. 44, no. 4, pp. 479–487, 2007.
- R. D. Schulteis, H. Chu, X. Dai, et al., “Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5,” Blood, vol. 112, no. 13, pp. 4905–4914, 2008.
- O. Stamm, J. Krücken, H.-P. Schmitt-Wrede, W. P. M. Benten, and F. Wunderlich, “Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32-36,” Gene, vol. 282, no. 1-2, pp. 159–167, 2002.
- L. Dahéron, T. Zenz, L. D. Siracusa, C. Brenner, and B. Calabretta, “Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activity,” Nucleic Acids Research, vol. 29, no. 6, pp. 1308–1316, 2001.
- T. Sandal, L. Aumo, L. Hedin, B. T. Gjertsen, and S. O. Døskeland, “Irod/Ian5: an inhibitor of -radiation- and okadaic acid-induced apoptosis,” Molecular Biology of the Cell, vol. 14, no. 8, pp. 3292–3304, 2003.
- S. Bieg, G. Koike, J. Jiang, et al., “Genetic isolation of iddm 1 on chromosome 4 in the biobreeding (BB) rat,” Mammalian Genome, vol. 9, no. 4, pp. 324–326, 1998.
- J. Krücken, M. Epe, W. P. M. Benten, N. Falkenroth, and F. Wunderlich, “Malaria-suppressible expression of the anti-apoptotic triple GTPase mGIMAP8,” Journal of Cellular Biochemistry, vol. 96, no. 2, pp. 339–348, 2005.
- T. Nitta, M. Nasreen, T. Seike, et al., “IAN family critically regulates survival and development of T lymphocytes,” PLoS Biology, vol. 4, no. 4, article e103, pp. 1–13, 2006.
- C. Carter, C. Dion, S. Schnell, et al., “A natural hypomorphic variant of the apoptosis regulator Gimap4/IAN1,” The Journal of Immunology, vol. 179, no. 3, pp. 1784–1795, 2007.
- J.-J. Filén, S. FiLén, R. Moulder, et al., “Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiation,” Molecular & Cellular Proteomics, vol. 8, no. 1, pp. 32–44, 2009.
- J. Lurton, T. M. Rose, G. Raghu, and A. S. Narayanan, “Isolation of a gene product expressed by a subpopulation of human lung fibroblasts by differential display,” American Journal of Respiratory Cell and Molecular Biology, vol. 20, no. 2, pp. 327–331, 1999.
- H. Nakajima, M. Takenaka, J.-Y. Kaimori, et al., “Gene expression profile of renal proximal tubules regulated by proteinuria,” Kidney International, vol. 61, no. 5, pp. 1577–1587, 2002.
- P. A. Frischmeyer and H. C. Dietz, “Nonsense-mediated mRNA decay in health and disease,” Human Molecular Genetics, vol. 8, no. 10, pp. 1893–1900, 1999.
- J. T. Mendell, N. A. Sharifi, J. L. Meyers, F. Martinez-Murillo, and H. C. Dietz, “Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise,” Nature Genetics, vol. 36, no. 10, pp. 1073–1078, 2004.
- T. L. Reuber and F. M. Ausubel, “Isolation of arabidopsis genes that differentiate between resistance responses mediated by the RPS2 and RPM1 disease resistance genes,” The Plant Cell, vol. 8, no. 2, pp. 241–249, 1996.
- G. M. C. Poirier, G. Anderson, A. Huvar, et al., “Immune-associated nucleotide-1 (IAN-1) is a thymic selection marker and defines a novel gene family conserved in plants,” The Journal of Immunology, vol. 163, no. 9, pp. 4960–4969, 1999.
- M. Cambot, S. Aresta, B. Kahn-Perlès, J. de Gunzburg, and P.-H. Roméo, “Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells,” Blood, vol. 99, no. 9, pp. 3293–3301, 2002.
- T. Zenz, A. Roessner, A. Thomas, et al., “hlan5: the human ortholog to the rat lan4/lddm1/lyp is a new member of the Ian family that is overexpressed in B-cell lymphoid malignancies,” Genes & Immunity, vol. 5, no. 2, pp. 109–116, 2004.
- J. A. Lang, D. Kominski, D. Bellgrau, and R. I. Scheinman, “Partial activation precedes apoptotic death in T cells harboring an IAN gene mutation,” European Journal of Immunology, vol. 34, no. 9, pp. 2396–2406, 2004.