Vascular and Neural Dysfunctions in Obese Zucker Rats: Effect of AVE7688
Figure 3
Determination of aorta superoxide and nitrotyrosine in epineurial arterioles of the sciatic nerve from lean and obese Zucker rats treated with AVE7688. Presented are representative fluorescent photomicrographs of confocal microscopic sections of aorta for nitrotyrosine staining. Lucigenin-based assay was used to determine superoxide levels in the aorta. The graphed data are presented as arbitrary light units with the value for lean rats assigned as 1. compared to untreated obese Zucker rats. These values were obtained from 2 different rats and 5 vessel segments were analyzed for each individual rat.
