Vascular and Neural Dysfunctions in Obese Zucker Rats: Effect of AVE7688

Table 1

Effect of obesity and treatment with AVE7688 on body weight, blood glucose, serum insulin, cholesterol, triglycerides, free fatty acids, and ACE activity, and thermal nociception and tactile allodynia.

Determination	Lean (17)	Obese (9)	Obese + AVE7688 (14)
Start weight (g)	190±4	216±7	216±7
End weight (g)	522±9	785±33 *	842±21 *
Blood glucose (mg/dL)	84±5	96±9	116±15
Insulin (ng/mL)	7.7±2.5	16.7±1.5 *	71.6±19.3^*+
Cholesterol (mg/mL)	6.0±0.6	18.0±3.5 *	15.9±4.0
Triglycerides (mg/dL)	2.53±0.40	13.60±2.14 *	8.21±1.68 *
Free fatty acids (mmol/L)	0.13±0.04	0.63±0.23 *	0.22±0.03
ACE activity (U/l)	37.5±3.4	211.2±26.4 *	38.0±5.7^+
Thermal nociception (sec)	12.8±0.4	20.3±0.8 *	15.4±0.9^+
Tactile 50% response threshold (g)	9.8±1.2	16.6±1.6 *	10.1±1.3^+

Data are presented as the mean ± SEM. *𝑃<.05 compared to lean, ⁺𝑃<.05 compared to obese. Parentheses indicate the number of experimental animals.