Changes in renal function. (a) and (b) there was a significant increase in urine and urine protein in diabetic rabbits as compared with baseline; (c) and (d) there was a statistically significant difference in blood urea nitrogen (BUN) and serum creatinine levels between the diabetic and age-matched nondiabetic rabbits at 9 and 12 months. (a) and (b) compared with baseline; (c) and (d) between diabetic and age-matched nondiabetic animals.
