The pathological changes of a 12-month diabetic rabbit. (a) and (b) There is marked damage to beta-cells (arrow); (c) and (d) the microscopic cross-section of the artery in the pancreas shows a thickened vessel wall (arrow); (e) and (f) Hyaline arteriolosclerosis. The amorphous, homogeneous eosinophilic material is seen in the thickened vascular wall of afferent glomerular arteriole and the lumen is narrowed markedly (arrow). Glomerular atrophy is also present; (g) and (h) lipid accumulation in the cytoplasm of the hepatocytes appearing as vacuoles (hepatic fatty degeneration); (i) and (j) the microscopic section of the aortic media showing mild spot calcifications (arrow).
