- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Annual Issues
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Reviewers Acknowledgment
- Submit a Manuscript
- Subscription Information
- Table of Contents
Experimental Diabetes Research
Volume 2010 (2010), Article ID 289614, 10 pages
Creating a Long-Term Diabetic Rabbit Model
1Department of Surgery, University of Louisville, MDR 316, Louisville, KY 40202, USA
2Department of Environmental and Occupational Health Sciences, University of Louisville, Louisville, KY 40202, USA
3Research Resources Facilities and Cardiovascular Innovation Institute, University of Louisville, Louisville, KY 40202, USA
Received 26 March 2010; Revised 25 August 2010; Accepted 23 November 2010
Academic Editor: Bernard Portha
Copyright © 2010 Jianpu Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- American Diabetic Association, National Diabetes Statistics Fact Sheet, 2008, http://diabetes.niddk.nih.gov/dm/pubs/statistics/index.htm.
- American-Diabetes-Association, “All about Diabetes,” 2007, http://www.diabetes.org/about-diabetes.jsp.
- G. H. Tesch and T. J. Allen, “Rodent models of streptozotocin-induced diabetic nephropathy (methods in renal research),” Nephrology, vol. 12, no. 3, pp. 261–266, 2007.
- S. Lenzen, “The mechanisms of alloxan- and streptozotocin-induced diabetes,” Diabetologia, vol. 51, no. 2, pp. 216–226, 2008.
- D. A. Rees and J. C. Alcolado, “Animal models of diabetes mellitus,” Diabetic Medicine, vol. 22, no. 4, pp. 359–370, 2005.
- S. H. Mir and M. M. Darzi, “Histopathological abnormalities of prolonged alloxan-induced diabetes mellitus in rabbits,” International Journal of Experimental Pathology, vol. 90, no. 1, pp. 66–73, 2009.
- A. Sepici-Dincel, Ş. Açikgöz, C. Çevik, M. Sengelen, and E. Yeşilada, “Effects of in vivo antioxidant enzyme activities of myrtle oil in normoglycaemic and alloxan diabetic rabbits,” Journal of Ethnopharmacology, vol. 110, no. 3, pp. 498–503, 2007.
- A. Breen, G. Mc Redmond, P. Dockery, T. O'Brien, and A. Pandit, “Assessment of wound healing in the alloxan-induced diabetic rabbit ear model,” Journal of Investigative Surgery, vol. 21, no. 5, pp. 261–269, 2008.
- J. Wang, Q. Zhang, R. Wan et al., “Intracellular adenosine triphosphate delivery enhanced skin wound healing in rabbits,” Annals of Plastic Surgery, vol. 62, no. 2, pp. 180–186, 2009.
- J. Wang, R. Wan, Y. Mo, M. Li, Q. Zhang, and S. Chien, “Intracellular delivery of adenosine triphosphate enhanced healing process in full-thickness skin wounds in diabetic rabbits,” American Journal of Surgery, vol. 199, no. 6, pp. 823–832, 2010.
- M. Chvapil, J. A. Gaines, and T. Gilman, “Lanolin and epidermal growth factor in healing of partial-thickness pig wounds,” Journal of Burn Care and Rehabilitation, vol. 9, no. 3, pp. 279–284, 1988.
- M. Gerharz, A. Baranowsky, U. Siebolts et al., “Morphometric analysis of murine skin wound healing: standardization of experimental procedures and impact of an advanced multitissue array techniqueMorphometric analysis of murine skin wound healing: standardization of experimental procedures and impact of an advanced multitissue array technique,” Wound Repair and Regeneration, vol. 15, no. 1, pp. 105–112, 2007.
- B. Guerci, N. Tubiana-Rufi, B. Bauduceau et al., “Advantages to using capillary blood β-hydroxybutyrate determination for the detection and treatment of diabetic ketosis,” Diabetes and Metabolism, vol. 31, no. 4, pp. 401–406, 2005.
- N. B. Bozkurt and C. Pekiner, “Impairment of endothelium- and nerve-mediated relaxation responses in the cavernosal smooth muscle of experimentally diabetic rabbits: role of weight loss and duration of diabetes,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 373, no. 1, pp. 71–78, 2006.
- H. Roy, S. Bhardwaj, M. Babu et al., “VEGF-A, VEGF-D, VEGF receptor-1, VEGF receptor-2, NF-kappaB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits,” The FASEB Journal, vol. 20, no. 12, pp. 2159–2161, 2006.
- T. Goseki, H. Ishikawa, H. Nishimoto et al., “Pharmacological vascular reactivity in isolated diabetic rabbit ciliary artery,” Experimental Eye Research, vol. 83, no. 6, pp. 1317–1324, 2006.
- V. Duzguner and S. Kaya, “Effect of zinc on the lipid peroxidation and the antioxidant defense systems of the alloxan-induced diabetic rabbits,” Free Radical Biology and Medicine, vol. 42, no. 10, pp. 1481–1486, 2007.
- N. Wadood, M. Nisar, A. Rashid, A. Wadood, . Gul-Nawab, and A. Khan, “Effect of a compound recipe (medicinal plants) on serum insulin levels of alloxan induced diabetic rabbits,” Journal of Ayub Medical College, Abbottabad, vol. 19, no. 1, pp. 32–38, 2007.
- M. Richardson, S. J. Hadcock, B. D. Hatton, P. D. Winocour, and M. W. C. Hatton, “Proteoglycan alterations in the aortic intima-media of alloxan-diabetic rabbits: an ultrastructural and biochemical study,” Experimental and Molecular Pathology, vol. 62, no. 3, pp. 145–159, 1995.
- J. S. Dunn and N. G. B. Mcletchie, “Experimental alloxan diabetes in the rats,” The Lancet, vol. 242, no. 6265, pp. 384–387, 1943.
- C. C. Rerup, “Drugs producing diabetes through damage of the insulin secreting cells,” Pharmacological Reviews, vol. 22, no. 4, pp. 485–518, 1970.
- G. L. Duff, D. J. Brechin, and W. E. Finkelstein, “The effect of alloxan diabetes on experimental cholesterol atherosclerosis in the rabbit. IV. The effect of insulin therapy on the inhibition of atherosclerosis in the alloxan-diabetic rabbit,” Journal of Experimental Medicine, vol. 100, no. 4, pp. 371–380, 1954.
- R. H. Bell Jr. and R. J. Hye, “Animal models of diabetes mellitus: physiology and pathology,” Journal of Surgical Research, vol. 35, no. 5, pp. 433–460, 1983.
- A. R. Spiegelman and M. Tuchman, “Prevention of hypoglycemia during the induction of alloxan diabetes; the use of glucose and anti-hyaluronidase subcutaneously in the rabbit,” Diabetes, vol. 4, no. 6, p. 473, 1955.
- B. W. Volk and E. R. Arquilla, Eds., The Diabetic Pancreas, Plenum, San Francisco, Calif, USA, 1985.
- Z. H. Zhao, B. Watschinger, C. D. Brown, M. M. Beyer, and E. A. Friedman, “Variations of susceptibility to alloxan induced diabetes in the rabbit,” Hormone and Metabolic Research, vol. 19, no. 11, pp. 534–537, 1987.
- I. J. Pincus, J. J. Hurwitz, and M. E. Scott, “Effect of rate of injection of alloxan on development of diabetes in rabbits,” Proceedings of the Society for Experimental Biology and Medicine, vol. 86, no. 3, pp. 553–554, 1954.
- G. Hadour, R. Ferrera, L. Sebbag, R. Forrat, J. Delaye, and M. De Lorgeril, “Improved myocardial tolerance to ischaemia in the diabetic rabbit,” Journal of Molecular and Cellular Cardiology, vol. 30, no. 9, pp. 1869–1875, 1998.
- D. Cheţa, “Animal models of type I (insulin-dependent) diabetes mellitus,” Journal of Pediatric Endocrinology and Metabolism, vol. 11, no. 1, pp. 11–19, 1998.
- S. A. Bencosme, “Cytology of islet cells in alloxan diabetic rabbits,” American Journal of Pathology, vol. 31, no. 6, pp. 1149–1163, 1955.
- R. E. Heikkila and F. S. Cabbat, “The prevention of alloxan-induced diabetes by amygdalin,” Life Sciences, vol. 27, no. 8, pp. 659–662, 1980.
- R. Monclús, H. G. Rödel, R. Palme, D. Von Holst, and J. De Miguel, “Non-invasive measurement of the physiological stress response of wild rabbits to the odour of a predator,” Chemoecology, vol. 16, no. 1, pp. 25–29, 2006.
- H. Watada, K. Azuma, and R. Kawamori, “Glucose fluctuation on the progression of diabetic macroangiopathy—new findings from monocyte adhesion to endothelial cells,” Diabetes Research and Clinical Practice, vol. 77, no. 3, supplement, pp. S58–S61, 2007.
- S. Al-Khoury, B. Afzali, N. Shah et al., “Diabetes, kidney disease and anaemia: time to tackle a troublesome triad?” International Journal of Clinical Practice, vol. 61, no. 2, pp. 281–289, 2007.
- D. Mathe, “Dyslipidemia and diabetes: animal models,” Diabete et Metabolisme, vol. 21, no. 2, pp. 106–111, 1995.
- G. D. Harris, I. Fiordalisi, and C. Yu, “Maintaining normal intracranial pressure in a rabbit model during treatment of severe diabetic ketoacidemia,” Life Sciences, vol. 59, no. 20, pp. 1695–1702, 1996.
- D. K. Singh, P. Winocour, and K. Farrington, “Erythropoietic stress and anemia in diabetes mellitus,” Nature Reviews Endocrinology, vol. 5, no. 4, pp. 204–210, 2009.
- N. S. Gibran, Y. C. Jang, F. F. Isik et al., “Diminished neuropeptide levels contribute to the impaired cutaneous healing response associated with diabetes mellitus,” Journal of Surgical Research, vol. 108, no. 1, pp. 122–128, 2002.
- P. Muangman, L. A. Muffley, J. P. Anthony et al., “Nerve growth factor accelerates wound healing in diabetic mice,” Wound Repair and Regeneration, vol. 12, no. 1, pp. 44–52, 2004.
- E. A. Friedman, “Advanced glycosylated end products and hyperglycemia in the pathogenesis of diabetic complications,” Diabetes Care, vol. 22, no. 2, pp. B65–B71, 1999.
- H. Yki-Järvinen, “Toxicity of hyperglycaemia in type 2 diabetes,” Diabetes/Metabolism Reviews, vol. 14, no. 1, supplement, pp. S45–S50, 1998.
- D. Porte Jr. and M. W. Schwartz, “Diabetes complications: why is glucose potentially toxic?” Science, vol. 272, no. 5262, pp. 699–700, 1996.