Creating a Long-Term Diabetic Rabbit Model

Table 1

Changes of several serum biochemical measurements over 12 months in diabetic rabbits.

Index	Baseline	3 months	6 months	9 month	12 months
ALT (u/l)	16±12	33±16	28±20	31±17	26±10
AST (u/l)	12±6	24±13	45±30^∗	31±18	25±9
LDH (u/l)	48±36	47±26	65±45	52±26	78±33
CK (u/l)	456±140	494±120	406±193	465±383	398±279
TP (g/dl)	5.7±1.5	5.4±1.6	6.9±1.9	5.6±1.0	6.3±1.3

ALT: alanine aminotransferase, AST: aspartate aminotransferase, LDH: lactate dehydrogenase, CK: creatine kinase, TP: total protein.
^∗𝑃<.05 versus Baseline.