Diabetic Nephropathy Amelioration by a Low-Dose Sitagliptin in an Animal Model of Type 2 Diabetes (Zucker Diabetic Fatty Rat)

Figure 2

Evolution of renal lesions with ageing in lean control and obese diabetic ZDF rats: (a) normal renal histology in a lean control rat at 20 weeks of age (PAS, 400x); (b) a glomerulus presenting grade 1 mesangial expansion and thickening of the capsule of Bowman in a lean control rat at 26 weeks of age (PAS, 400x); (c) nodular glomerulosclerosis with sinequia of the tuft to Bowman’s capsule, mesangial expansion and arteriolar sclerosis in a diabetic rat of 20 weeks (PAS, 400x); (d) atrophic, sclerosed glomerulus, exhibiting filtrate fluid in Bowman’s space. Note the presence of hyaline cylinders and the irregularity of tubular basement membranes, diabetic rat of 26 weeks (PAS, 200x).