Diabetic Nephropathy Amelioration by a Low-Dose Sitagliptin in an Animal Model of Type 2 Diabetes (Zucker Diabetic Fatty Rat)

Figure 3

Effects of chronic sitagliptin treatment on renal lesions in obese diabetic ZDF rats; (a) regression of glomerulosclerosis, with more glomeruli presenting the more benign nodular form of sclerosis; (b) reduction in capsule of Bowman thickness and absence of sclerosis; (c) although there is persistence of grade 2 capsular thickening, there is absence of sclerosis and only the presence of grade 1 mesangial expansion; (d) presence of light mesangial expansion and hyalinosis of the vascular pole. Note in all figures the absence of hyaline cylinders and a more regular contour of the tubular basement membranes PAS, 400x.