Diabetic Nephropathy Amelioration by a Low-Dose Sitagliptin in an Animal Model of Type 2 Diabetes (Zucker Diabetic Fatty Rat)

Table 2

Assessment of kidney function (serum creatinine and BUN) and weights (trophism) in the lean control and diabetic ZDF rats at the initial and final time (6 weeks of vehicle or sitagliptin treatment).

Time	Initial time (20 wks)		Final time (26 wks)
Rat group	Lean control	Obese diabetic	Lean control	Obese diabetic
Parameters	(𝑛=16)	(𝑛=16)	Vehicle (𝑛=8)	Vehicle (𝑛=8)	SITA (𝑛=8)
Creatinine (mg/dL)	0.55±0.03	0.55±0.06	0.53±0.03	0.54±0.08	0.49±0.04
BUN (μg/L)	14.35±0.47	18.15±0.84^aaa	15.05±0.54	18.03±1.20^aa	15.16±0.61^b
KW (g)	2.39±0.08	3.25±0.26^a	2.56±0.04	3.02±0.09^a	3.15±0.05
KW/BW (g/Kg)	6.11±0.15	8.82±0.73^a	5.71±0.07	8.42±0.42^aaa	8.42±0.40

Values are means ± SEM of 𝑛 rats. Comparisons between groups: ^alean control (vehicle) versus obese diabetic (vehicle) rats; ^bdiabetic SITA-treated versus diabetic untreated rats. One, two, or three letters for 𝑃<0.05, 𝑃<0.01, and 𝑃<0.001, respectively. BUN: blood urea nitrogen; BW: body weight; KW: kidney weight; SITA: sitagliptin; ZDF: Zucker diabetic fatty.