Review Article
Exocrine Pancreatic Insufficiency in Diabetes Mellitus: A Complication of Diabetic Neuropathy or a Different Type of Diabetes?
Table 1
Results of direct pancreatic function tests in patients with diabetes mellitus.
| Author | Year | Subjects/diabetes type | Methods | Results |
| Pollard et al. [1] | 1943 | 13 | Amylase and lipase after pancreozymin-secretin stimulation | 62% reduced | Chey et al. [2] | 1963 | 50 diabetic patients; 13 juvenile type | Amylase and lipase after pancreozymin-secretin stimulation | Low amylase output in diabetes: 36%; in juvenile diabetes: 77% | Vacca et al. [3] | 1964 | 55 diabetic patients (22 insulin treated) | Diastase and bicarbonate after secretin stimulation; fecal fat | 73% abnormal; correlation with age, no correlation with fecal fat | Frier et al. [4] | 1976 | 20 IDDM, 7 NIDDM, 13 controls | Stimulation with iv secretin and CCK-PZ | PEI: 80% IDDM; correlation with diabetes duration | Harano et al. [20] | 1978 | 53 NIDDM, 4 IDDM, 18 controls | Secretin-pancreozymin test | Diabetes: 69% deficient enzyme output; correlation with diabetes control | Lankisch et al. [5] | 1982 | 53 IDDM | Secretin-pancreozymin test | Diabetes: 43% impaired function |
Bretzke et al. [21] | 1984 | 60 insulin-treated type 2 diabetic patients | Secretin-pancreozymin test | Diabetes: 27% “mild PEI” | El Newihi et al. [22] | 1988 | 10 type 2 diabetic patients with diarrhea and neuropathy | Secretin and CCK test | Enzyme and bicarbonate reduction in all subjects |
|
|