Decreased Skin-Mediated Detoxification Contributes to Oxidative Stress and Insulin Resistance

Figure 7

Proposed role of skin in oxidative stress and IR. The body’s total antioxidant capacity, consisting of biotransformation system, excretion system, and reactive oxygen species clearance system, depends on the functions of body’s tissues/organs. A decrease in the skin contribution, such as induced by severe burn and cold ambient environment, decreases the body’s total antioxidant capacity and thus increases the risk for oxidative stress and subsequent IR. OK: the body’s total antioxidant capacity > ROS generation; OS: oxidative stress, that is, ROS generation > the body’s total antioxidant capacity.