- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Annual Issues
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Reviewers Acknowledgment
- Submit a Manuscript
- Subscription Information
- Table of Contents
Experimental Diabetes Research
Volume 2012 (2012), Article ID 147965, 8 pages
Inhibition of Aldose Reductase by Gentiana lutea Extracts
1Biochemistry Division, National Institute of Nutrition, Tarnaka, Jamai-Osmania, Hyderabad 500 007, India
2 Vinca Institute of Nuclear Sciences, University of Belgrade, 11001 Belgrade, Serbia
3Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO 80045, USA
Received 3 March 2012; Accepted 22 May 2012
Academic Editor: Subrata Chakrabarti
Copyright © 2012 Chandrasekhar Akileshwari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- S. Wild, G. Roglic, A. Green, R. Sicree, and H. King, “Global prevalence of diabetes: estimates for the year 2000 and projections for 2030,” Diabetes Care, vol. 27, no. 5, pp. 1047–1053, 2007.
- M. Brownlee, “Biochemistry and molecular cell biology of diabetic complications,” Nature, vol. 414, no. 6865, pp. 813–820, 2001.
- J. H. Kinoshita, “A thirty year journey in the polyol pathway,” Experimental Eye Research, vol. 50, no. 6, pp. 567–573, 1990.
- A. Bhatnagar and S. K. Srivastava, “Aldose reductase: congenial and injurious profiles of an enigmatic enzyme,” Biochemical Medicine and Metabolic Biology, vol. 48, no. 2, pp. 91–121, 1992.
- P. F. Kador, J. H. Kinoshita, and N. E. Sharpless, “Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications,” Journal of Medicinal Chemistry, vol. 28, no. 7, pp. 841–849, 1985.
- N. Hotta, T. Toyota, K. Matsuoka et al., “Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study,” Diabetes Care, vol. 24, no. 10, pp. 1776–1782, 2001.
- P. Raskin and J. Rosenstock, “Aldose reductase inhibitors and diabetic complications,” The American Journal of Medicine, vol. 83, no. 2, pp. 298–306, 1987.
- M. A. Pfeifer, M. P. Schumer, and D. A. Gelber, “Aldose reductase inhibitors: the end of an era or the need for different trial designs?” Diabetes, vol. 46, supplement 2, pp. S82–S89, 1997.
- P. J. Oates and B. L. Mylari, “Aldose reductase inhibitors: therapeutic implications for diabetic complications,” Expert Opinion on Investigational Drugs, vol. 8, no. 12, pp. 2095–2119, 1999.
- P. F. Kador, W. G. Robison, and J. H. Kinoshita, “The pharmacology of aldose reductase inhibitors,” Annual Review of Pharmacology and Toxicology, vol. 25, pp. 691–714, 1985.
- P. Suryanarayana, P. A. Kumar, M. Saraswat, J. M. Petrash, and G. B. Reddy, “Inhibition of aldose reductase by tannoid principles of Emblica officinalis: implications for the prevention of sugar cataract,” Molecular Vision, vol. 10, pp. 148–154, 2004.
- P. Suryanarayana, M. Saraswat, J. M. Petrash, and G. B. Reddy, “Emblica officinalis and its enriched tannoids delay streptozotocin-induced diabetic cataract in rats,” Molecular Vision, vol. 24, pp. 1291–1297, 2007.
- M. Saraswat, P. Muthenna, P. Suryanarayana, J. M. Petrash, and G. B. Reddy, “Dietary sources of aldose reductase inhibitors: prospects for alleviating diabetic complications,” Asia Pacific Journal of Clinical Nutrition, vol. 17, no. 4, pp. 558–565, 2008.
- P. Muthenna, P. Suryanarayana, S. Gunda, J. M. Petrash, and G. B. Reddy, “Inhibition of aldose reductase by dietary antioxidant curcumin: mechanism of inhibition, specificity and significance,” FEBS Letters, vol. 583, no. 22, pp. 3637–3642, 2009.
- G. B. Reddy, P. Muthenna, C. Akileshwari, M. Saraswat, and J. M. Petrash, “Inhibition of aldose reductase and sorbitol accumulation by dietary rutin,” Current Science, vol. 101, no. 9, pp. 1191–1197, 2011.
- M. Daniel and S. D. Sabnis, “Chemical systematics of family Gentianaceae,” Current Science, vol. 47, no. 4, pp. 109–111, 1978.
- J. M. Petrash, T. M. Harter, C. S. Devine et al., “Involvement of cysteine residues in catalysis and inhibition of human aldose reductase. Site-directed mutagenesis of Cys-80, -298, and -303,” The Journal of Biological Chemistry, vol. 267, no. 34, pp. 24833–24840, 1992.
- J. I. Malone, G. Knox, S. Benford, and T. A. Tedesco, “Red cell sorbitol: an indicator of diabetic control,” Diabetes, vol. 29, no. 11, pp. 861–864, 1980.
- R. Hänsel and O. Sticher, Pharmakognosie-Phytopharmazie, vol. 8, Springer, Heidelberg, Germany, 2007.
- M. Wichtl, Teedrogen und Phytotherapeutika, vol. 4, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, Germany, 2002.
- A. Aberham, S. Schwaiger, H. Stuppner, and M. Ganzera, “Quantitative analysis of iridoids, secoiridoids, xanthones and xanthone glycosides in Gentiana lutea L. roots by RP-HPLC and LC-MS,” Journal of Pharmaceutical and Biomedical Analysis, vol. 45, no. 3, pp. 437–442, 2007.
- N. Öztürk, S. Korkmaz, Y. Öztürk, and K. H. Başer, “Effects of gentiopicroside, sweroside and swertiamarine, secoiridoids from gentian (Gentiana lutea ssp. symphyandra), on cultured chicken embryonic fibroblasts,” Planta Medica, vol. 72, no. 4, pp. 289–294, 2006.
- I. Citová, M. Ganzera, H. Stuppner, and P. Solich, “Determination of gentisin, isogentisin, and amarogentin in Gentiana lutea L. by capillary electrophoresis,” Journal of Separation Science, vol. 31, no. 1, pp. 195–200, 2008.
- A. Singh, “Phytochemicals of gentianaceae: a review of pharmacological properties,” International Journal of Pharmaceutical Sciences and Nanotechnology, vol. 1, no. 1, pp. 33–36, 2008.
- A. Schmieder, S. Schwaiger, A. Csordas et al., “Isogentisin—a novel compound for the prevention of smoking-caused endothelial injury,” Atherosclerosis, vol. 194, no. 2, pp. 317–325, 2007.
- B. Crosas, D. J. Hyndman, O. Gallego et al., “Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism,” The Biochemical Journal, vol. 373, part 3, pp. 973–979, 2003.
- A. D. Morrison, R. S. Clements, and A. I. Winegrad, “Effects of elevated glucose concentrations on the metabolism of the aortic wall,” The Journal of Clinical Investigation, vol. 51, no. 12, pp. 3114–3123, 1972.
- G. B. Reddy, A. Satyanarayana, N. Balakrishna et al., “Erythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy,” Molecular Vision, vol. 14, pp. 593–601, 2008.
- D. R. Tomlinson, E. J. Stevens, and L. T. Diemel, “Aldose reductase inhibitors and their potential for the treatment of diabetic complications,” Trends in Pharmacological Sciences, vol. 15, no. 8, pp. 293–297, 1994.
- N. Öztürk, T. Herekman-Demir, Y. Öztürk, B. Bozan, and K. H. C. Başer, “Choleretic activity of Gentiana lutea ssp. symphyandra in rats,” Phytomedicine, vol. 5, no. 4, pp. 283–288, 1998.
- A. Kušar, A. Zupančič, M. Šentjurc, and D. Baričevič, “Free radical scavenging activities of yellow gentian (Gentiana lutea L.) measured by electron spin resonance,” Human and Experimental Toxicology, vol. 25, no. 10, pp. 599–604, 2006.
- A. Mathew, A. D. Taranalli, and S. S. Torgal, “Evaluation of anti-inflammatory and wound healing activity of Gentiana lutea rhizome extracts in animals,” Pharmaceutical Biology, vol. 42, no. 1, pp. 8–12, 2004.
- J. Bruneton, Pharmacognosy, Lavoisier Publishing, Paris, France, 1999.
- M. Hostettmann-Kaldas, K. Hostettmann, and O. Sticher, “Xanthones, flavones and secoiridoids of American Gentiana species,” Phytochemistry, vol. 20, no. 3, pp. 443–446, 1981.