Differential Proteome Profiling Using iTRAQ in Microalbuminuric and Normoalbuminuric Type 2 Diabetic Patients
Figure 7
ROC curves and interactive plots for MRM validation in normoalbuminuric versus microalbuminuric urine. Seven biomarker candidates (TF, CP, A1AT, VDBP, AGP1, HP, and PSCA) were validated by MRM, in which 9 normoalbuminuric and 14 microalbuminuric urine samples were used. (a)–(g) Interactive plots and ROC curves for TF, CP, A1AT, VDBP, AGP1, HP, and PSCA. In the ROC curves, the solid lines represent the corresponding score in sensitivity (x-axis) and 100-specificity (y-axis). In the interactive plots, the -axis indicates the normalized concentration of the target protein against the spiked internal standard (50 fmol of beta-galactosidase peptide). Sens. and Spec. represent the sensitivity and specificity for the target proteins, respectively. The AUC values are shown inside the ROC curves.
