Hyperglycemia Increases Muscle Blood Flow and Alters Endothelial Function in Adolescents with Type 1 Diabetes
Table 1
Blood pressure, EPC, inflammatory and oxidative measures during hyperglycemic clamp and euglycemic control clamp. All values are expressed as mean ± standard error.
Hyperglycemia clamp ()
Overall value
Euglycemia control clamp ()
Overall value
Fasting
Euglycemia
Hyperglycemia
Fasting
Euglycemia 1
Euglycemia 2
Systolic blood pressure (mmHg)
105 ± 2
107 ± 2
113 ± 2*
<0.001
102 ± 2
107 ± 2*
113 ± 4
0.003
Diastolic blood pressure (mmHg)
61 ± 3
63 ± 3
61 ± 2
NS
57 ± 4
58 ± 2
61 ± 3
NS
Mean arterial pressure (mmHg)
75 ± 2
77 ± 2
79 ± 2
NS
72 ± 2
74 ± 2
78 ± 2
NS
Reactive hyperemia (% change in FVR)
−82.1 ± 1.3
−80 ± 1.6
−77.7 ± 2.6
NS
−84.1 ± 1.2
−77.9 ± 2.4#
−79.6 ± 2.5
0.083
Antioxidant capacity (mM Trolox equivalent)
108 ± 8
106 ± 7
98 ± 6
NS
129 ± 2
126 ± 2
118 ± 2*†
0.001
sICAM (ng/mL)
162 ± 7
156 ± 8
151 ± 7
0.002
155 ± 10
151 ± 13
146 ± 11
NS
hsCRP (mg/L)
0.95 ± 0.65
0.98 ± 0.67
0.82 ± 0.60
0.057
0.75 ± 0.27
0.68 ± 0.24
0.68 ± 0.26†
0.049
versus previous study phase, versus fasting, versus fasting.
