Increased Inflammation in Atherosclerotic Lesions of Diabetic Akita-LDLr−/− Mice Compared to Nondiabetic LDLr−/− Mice
Figure 2
Male mice have increased atherosclerosis compared to male mice. Mice were sacrificed at 24 weeks of age and atherosclerosis were quantified both in en face preparations of the aorta (a) as well as in sections from the aortic root (b). Percentage plaque area of total vessel area in the aorta and representative en face preparations of the aortas stained with Oil red O (dark red-colored) are presented in (a) and subvalvular lesion areas are presented in (b). Values are presented as individual mice and as mean ± SEM. Two-way ANOVA revealed interactions between diabetes and gender ((a)**, (b)***), and significant effect of diabetes ((a)***, (b)***) and of gender (b)***. Bonferroni post hoc test yielded **, ***. Scale bar = 2 mm.
