Protective Effects of Beta Glucan and Gliclazide on Brain Tissue and Sciatic Nerve of Diabetic Rats Induced by Streptozosin

Table 1

Biochemical parameters in all groups in the brain of rats.

Groups	MDA; (nmol/gr protein)	TOS; (mmol H2O2 Eq./g protein)	TAS; (mmol Trolox Eq./g protein)	OSI	Catalase; (U/g protein)	PON-1 activity; (U/mg protein)
Control (I)	259.9±60.5	22.0±8.2	0.44±0.1	53.6±25.5	1.19±0.14	0.72±0.29
Diabetic (II)	454.7±62.8	39.7±3.5	0.22±0.08	204.9±96.3	0.65±0.15	0.30±0.05
Diabetic + gliclazide (III)	367.4±47.6	32.2±2.8	0.29±0.04	113.7±17.1	0.73±0.12	0.40±0.10
Diabetic + Beta glucan (IV)	329.2±45.3	27.0±5.9	0.38±0.08	75.0±26.9	1.02±0.09	0.59±0.26
Gliclazide (V)	242.0±36.7	20.5±6.3	0.44±0.1	51.01±28.7	1.34±0.23	0.80±0.18
Beta glucan (VI)	257.0±55.0	21.8±6.8	0.46±0.11	52.7±33.4	1.30±0.26	0.71±0.20
P values
I-II	0.002	0.004	0.003	0.002	0.002	0.004
II-III	0.009	0.009	N.S.	0.009	N.S.	0.046
II–IV	0.002	0.004	0.012	0.002	0.002	0.016
I–VI	N.S.	N.S.	N.S.	N.S.	N.S.	N.S.
I–V	N.S.	N.S.	N.S.	N.S.	N.S.	N.S.

N.S: not significant, MDA: malondialdehyde, TOS: total oxidant status, TAS: total antioxidant status, OSI: oxidative stress index, PON-1: paraoxonase.