Research Article
The Influence of Type 2 Diabetes and Glucose-Lowering Therapies on Cancer Risk in the Taiwanese
Table 4
Adjusted odds ratios and 95% confidence intervals for specific cancers associated with antidiabetic drugs.
| | Site-specific cancer | Metformin | Sulfonylurea | Insulin | Age-sex-adjusted odds ratio | Age-sex-adjusted odds ratio | | () | () | () | (95% CI) | (95% CI) | | Cases/ | % | Cases/ | % | Cases/ | % | Insulin versus metformin | Sulfonylureas versus metformin |
| | Breast* | 19/2048 | 0.93 | 48/2804 | 1.71 | 5/338 | 1.48 | 1.630 (0.604–4.396) | 1.765 (1.030–3.024) | | Prostate* | 27/1915 | 1.41 | 52/3268 | 1.59 | 5/413 | 1.21 | 0.893 (0.338–2.359) | 1.034 (0.644–1.659) | | Colon and rectum | 46/3963 | 1.16 | 145/6072 | 2.39 | 18/751 | 2.40 | 2.135 (1.226–3.717) | 1.847 (1.320–2.585) | | Lung | 45/3963 | 1.14 | 122/6072 | 2.01 | 9/751 | 1.20 | 1.058 (0.513–2.183) | 1.570 (1.110–2.220) | | Liver | 58/3963 | 1.46 | 143/6072 | 2.36 | 19/751 | 2.53 | 1.818 (1.075–3.077) | 1.504 (1.104–2.049) | | Stomach | 20/3963 | 0.50 | 54/6072 | 0.89 | 7/751 | 0.93 | 1.855 (0.779–4.419) | 1.547 (0.923–2.594) | | Pancreas | 8/3963 | 0.20 | 21/6072 | 0.35 | 1/751 | 0.13 | 0.693 (0.087–5.545) | 1.594 (0.705–3.619) |
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*Breast cancer and prostate cancer were only adjusted for age but not sex.
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