Hepatic Mitochondrial Alterations and Increased Oxidative Stress in Nutritional Diabetes-Prone Psammomys obesus Model

Table 1

Body weight and biochemical parameters of control (n = 10) and high caloric diet-fed Psammomys rats (n = 15). Each run was performed in duplicate. *P < 0.05, **P < 0.01, ***P < 0.001 versus control rat group (natural food).

Parameter	Control (18 weeks)	Diabetic (18 weeks)
Initial body wt (g)	87.8 ± 3.3	85 ± 3.9
Final body wt (g)	121.5 ± 4.1	138.5 ± 8.7*
Hepatic mass/body wt ratio (%)	3.4 ± 0.09	4.05 ± 0.12*
Glucose (mg/dL)	65.2 ± 0.03	267 ± 0.5**
Insulin (pmol/L)	166.5 ± 1.8	1439 ± 3.3***
Triglycerides (mg/dL)	74.6 ± 19	253 ± 45.4**
Cholesterol (mg/dL)	61 ± 4.2	145.7 ± 4.9**
HDL-C (mg/dL)	44.2 ± 3.3	48.5 ± 7.2
LDL-C (mg/dL)	17.8 ± 1.3	29.5 ± 3.2*
Hepatic total lipids (mg/100 g wet wt)	3720 ± 90	4900 ± 190*
Hepatic triglycerides (mg/100 g wet wt)	291 ± 19	654 ± 79**
Hepatic cholesterol (mg/100 g wet wt)	273 ± 11	322 ± 21*
Urea (mg/dL)	53.8 ± 4.6	73.6 ± 6.9*
Creatinine (mg/dL)	0.28 ± 0.05	0.45 ± 0.02*
ALT (U/L)	76 ± 8.4	136 ± 19**
AST (U/L)	86 ± 6.7	167 ± 25**