465282.fig.003a
(a)
465282.fig.003b
(b)
465282.fig.003c
(c)
Figure 3: Compound C abolishes the effect of metformin on FGF21 expression. (a) FGF21 mRNA, (b) FGF21 protein, and (c) G6Pase mRNA expression in primary rat hepatocytes incubated for 24 hrs with Compound C in presence of 1000 μM metformin. Data are means ± SEM; , versus 0 μM Compound C treated-hepatocytes, , versus nontreated hepatocytes, analyzed by paired Student’s t-test, –5.